Immunogen sequence: MLMAWCRGPV LLCLRQGLGT NSFLHGLGQE PFEGARSLCC RSSPRDLRDG EREHEAAQRK APGAESCPSL PLSISDIGTG CLSSLENLRL PTLREESSPR ELEDSSGDQG RCGPTHQGSE DPSMLSQAQS ATEVEERHVS PSCSTSRERP FQAGELILAE TGEGETKFKK LFRLNNFGLL NSNWGAVPFG KIVGKFPGQI LRSSFGKQYM LRRPALEDYV VLMKRGTAIT FPKDINMILS MMDINPGDTV; Positive Samples: Mouse liver; Cellular Location: Mitochondrion
In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state. It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
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Protein Aliases: mRNA methyladenosine-N(1)-methyltransferase; potential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61B; potential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B; tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial; tRNA methyltransferase 61 homolog B
Gene Aliases: TRMT61B
UniProt ID: (Human) Q9BVS5
Entrez Gene ID: (Human) 55006