Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LCAL3; lung cancer associated lncRNA 3; mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase; Mitochondrial tRNA-specific 2-thiouridylase 1; MTO2; MTO2 homolog; MTU1; TRMT; TRMT1
Gene Aliases: LCAL3; MTO2; MTU1; TRMT; TRMT1; TRMU; TRNT1
UniProt ID: (Human) O75648
Entrez Gene ID: (Human) 55687