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Alomone Labs, LTD

TRPA1 (extracellular) Polyclonal Antibody, FITC

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TRPA1 (extracellular) Polyclonal Antibody, FITC

Product Details

ACC-037-F-50UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)NSTGIINETSDHSE,corresponding to amino acid residues 747-760 of human TRPA1, 1st extracellular loop
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1; cation channel; nompC; transformation-sensitive protein p120; transient receptor potential A1; transient receptor potential A1 ion channel; Transient Receptor Potential Ankyrin 1; TRPA-1; TRPA1; unnamed protein product; wasabi receptor

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Gene Aliases: ANKTM1; FEPS; FEPS1; p120; rTRPA1; TRPA1b

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UniProt ID: (Human) O75762, (Mouse) Q8BLA8, (Rat) Q6RI86

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Entrez Gene ID: (Human) 8989, (Mouse) 277328, (Rat) 312896

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Function(s)
ion channel activity voltage-gated calcium channel activity calcium channel activity channel activity calcium-release channel activity gated channel activity identical protein binding temperature-gated cation channel activity osmolarity-sensing cation channel activity protein binding
Process(es)
system process ion transport cellular calcium ion homeostasis cell surface receptor signaling pathway response to cold urinary bladder smooth muscle contraction sensory perception of pain calcium-mediated signaling cellular response to stress cellular response to heat positive regulation of insulin secretion involved in cellular response to glucose stimulus vasodilation thermoception detection of chemical stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception protein homotetramerization transmembrane transport cellular response to hydrogen peroxide cellular response to cold calcium ion transmembrane transport cellular response to food cellular response to carbon dioxide cellular response to caffeine ureteric peristalsis cellular response to toxic substance calcium ion transmembrane import into cytosol regulation of neuronal action potential cellular response to oxygen-containing compound regulation of blood circulation positive regulation of monoatomic anion transport calcium ion transport response to xenobiotic stimulus response to hydrogen peroxide response to pain detection of mechanical stimulus involved in sensory perception of pain
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