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|Tested species reactivity||Human, Rat|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from aa region 730-830 of human TRPC3 conjugated to an immunogenic carrier protein was used as the antigen|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:300-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion. Abundantly expressed in brain. Concentrated in cerebellar Purkinje cells and sparsely localized in cerebellar granule lyer, pontine nuclei and thalamus. Lower levels detected in other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
capacitative calcium channel TRPC7; focal segmental glomerulosclerosis 2; hTrp-3; hTRP7; ion channel protein; likley ortholog of mouse transient receptor potential cation channel, subfamily C, member 7; putative capacitative calcium channel; short transient receptor potential channel 3; short transient receptor potential channel 6; short transient receptor potential channel 7; transient receptor potential cation channel subfamily C member 3; transient receptor potential cation channel subfamily C member 3 variant c; transient receptor potential cation channel, subfamily C, member 3; transient receptor potential cation channel, subfamily C, member 6; transient receptor potential cation channel, subfamily C, member 7; transient receptor protein 3; transient receptor protein 6; transient receptor protein 7; TRP-6; TRP-7; trp-related protein 3; Trpc3; Trpc6; Trpc7
FSGS2; SCA41; TRP3; TRP6; TRP7; TRPC3; TrpC3c; TRPC6; TRPC7; Trrp3; Trrp6