Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
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Protein Aliases: BCLF-1, RCHF1, REHF-1, TBRBP, TRSLN; C3PO; Component 3 of promoter of RISC; recombination hotspot associated factor; recombination hotspot-binding protein; testis brain-RNA binding protein; Translin
Gene Aliases: BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN; TSN
UniProt ID: (Human) Q15631
Entrez Gene ID: (Human) 7247