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TSPAN8 (tetraspanin 8), also known as TM4SF3 or CO-029, is a 237 amino acid multi-pass membrane protein that belongs to the tetraspanin family of transmembrane proteins and is thought to play a role in signal transduction events that influence cell development, activation, growth and motility. Localized to the cell membrane, TSPAN8 is expressed in colon, gastric, renal and pancreatic cancers, strongly suggesting a role in cancer formation and metastasis. The gene encoding TSPAN8 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
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Protein Aliases: Tetraspanin-8; Tetraspanin8; Transmembrane 4 superfamily member 3; Tspan-8; Tumor-associated antigen CO-029
Gene Aliases: CO-029; TM4SF3; TSPAN8
UniProt ID: (Human) P19075
Entrez Gene ID: (Human) 7103
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