The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Protein Aliases: Protein SMG10; smg-10 homolog, nonsense mediated mRNA decay factor; Tel two interacting protein 1; TEL2-interacting protein 1 homolog; TELO2-interacting protein 1 homolog
Gene Aliases: KIAA0406; smg-10; SMG10; TTI1
UniProt ID: (Human) O43156
Entrez Gene ID: (Human) 9675