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This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: endoplasmic reticulum protein ERp46; Endoplasmic reticulum resident protein 46; endothelial protein disulphide isomerase; ER protein 46; FLJ21353; FLJ90810; MGC3178; protein disulfide isomerase family A, member 15; thiore; thioredoxin domain containing 5 (endoplasmic reticulum); Thioredoxin domain-containing protein 5; thioredoxin related protein; Thioredoxin-like protein p46
Gene Aliases: ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8; TLP46; TXNDC5; UNQ364; UNQ364/PRO700
UniProt ID: (Human) Q8NBS9
Entrez Gene ID: (Human) 81567
Molecular Function: chaperone