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Abnova
TYK2 Monoclonal Antibody (6H1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
H00007297-M03
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6H1
Immunogen
TYK2 (AAH14243, 276 a.a. approximately 375 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: PVCHLRLLAQ AEGEPCYIRD SGVAPTDPGP ESAAGPPTHE VLVTGTGGIQ WWPVEEEVNK EEGSSGSSGR NPQASLFGKK AKAHKAFGQP ADRPREPLWA
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; unnamed protein product
Gene Aliases: IMD35; JTK1
UniProt ID: (Human) P29597
Entrez Gene ID: (Human) 7297
protein phosphorylation
JAK-STAT cascade
cell proliferation
cytokine-mediated signaling pathway
regulation of cell-cell adhesion
cell differentiation
intracellular signal transduction
interleukin-12-mediated signaling pathway
interleukin-5-mediated signaling pathway
interleukin-23-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of cell adhesion
regulation of JAK-STAT cascade
regulation of alpha-beta T cell activation
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-10-mediated signaling pathway
positive regulation of protein localization to nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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