Immunogen sequence: QEGTYLATIH LPYLQGQVTL ELAVYKPPKV SLMPATLARA APGEAPPELL CLVSHFYPSG GLEVEWELRG GPGGRSQKAE GQRWLSALRH HSDGSVSLSG HLQPPPVTTE QHGARYACRI HHPS
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 77%.
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
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Protein Aliases: DADB-159G18.7; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin; TPN
Gene Aliases: NGS17; TAPA; TAPBP; TPN; TPSN
UniProt ID: (Human) O15533
Entrez Gene ID: (Human) 6892