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Invitrogen

Thrombospondin 1 Recombinant Rabbit Monoclonal Antibody (K01_2P75)

View all (25) Thrombospondin 1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA564220

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

K01_2P75

Immunogen

Recombinant protein of human Thrombospondin 1 (aa 547-1170).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl

Contains

0.01% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunogen sequence: PIDGCLSNPC FAGVKCTSYP DGSWKCGACP PGYSGNGIQC TDVDECKEVP DACFNHNGEH RCENTDPGYN CLPCPPRFTG SQPFGQGVEH ATANKQVCKP RNPCTDGTHD CNKNAKCNYL GHYSDPMYRC ECKPGYAGNG IICGEDTDLD GWPNENLVCV ANATYHCKKD NCPNLPNSGQ EDYDKDGIGD ACDDDDDNDK IPDDRDNCPF HYNPAQYDYD RDDVGDRCDN CPYNHNPDQA DTDNNGEGDA CAADIDGDGI LNERDNCQYV YNVDQRDTDM DGVGDQCDNC PLEHNPDQLD SDSDRIGDTC DNNQDIDEDG HQNNLDNCPY VPNANQADHD KDGKGDACDH DDDNDGIPDD KDNCRLVPNP DQKDSDGDGR GDACKDDFDH DSVPDIDDIC PENVDISETD FRRFQMIPLD PKGTSQNDPN WVVRHQGKEL VQTVNCDPGL AVGYDEFNAV DFSGTFFINT ERDDDYAGFV FGYQSSSRFY VVMWKQVTQS YWDTNPTRAQ GYSGLSVKVV NSTTGPGEHL RNALWHTGNT PGQVRTLWHD PRHIGWKDFT AYRWRLSHRP KTGFIRVVMY EGKKIMADSG PIYDKTYAGG RLGLFVFSQE MVFFSDLKYE CRDP

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 54%, Pig - 99%, Cynomolgus monkey - 99%.

Target Information

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Glycoprotein G; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1

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Gene Aliases: tbsp1; THBS; THBS-1; THBS1; TSP; TSP-1; TSP1

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UniProt ID: (Human) P07996

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Entrez Gene ID: (Human) 7057, (Mouse) 21825

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Function(s)
phosphatidylserine binding glycoprotein binding fibronectin binding integrin binding calcium ion binding protein binding heparin binding fibroblast growth factor binding low-density lipoprotein particle binding identical protein binding laminin binding proteoglycan binding transforming growth factor beta binding fibrinogen binding collagen V binding extracellular matrix binding
Process(es)
activation of MAPK activity response to hypoxia negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion sprouting angiogenesis chronic inflammatory response platelet degranulation negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation inflammatory response immune response response to unfolded protein cell cycle arrest cell adhesion response to glucose positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of plasma membrane long-chain fatty acid transport negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration cell migration negative regulation of angiogenesis peptide cross-linking positive regulation of blood coagulation extracellular matrix organization positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway regulation of cGMP metabolic process response to magnesium ion response to progesterone negative regulation of interleukin-12 production positive regulation of transforming growth factor beta1 production cellular response to heat response to endoplasmic reticulum stress protein O-linked fucosylation negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation response to drug positive regulation of tumor necrosis factor biosynthetic process positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain positive regulation of chemotaxis response to calcium ion negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of fibrinolysis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis negative regulation of extrinsic apoptotic signaling pathway outflow tract morphogenesis endocardial cushion development growth plate cartilage development response to mechanical stimulus positive regulation of cell-substrate adhesion blood vessel morphogenesis positive regulation of transforming growth factor beta production cellular response to nitric oxide
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