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Invitrogen

Thrombospondin 1 Recombinant Rabbit Monoclonal Antibody (K01_2P75)

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Thrombospondin 1 Recombinant Rabbit Monoclonal Antibody (K01_2P75)

Product Details

MA564220

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

K01_2P75

Immunogen

Recombinant protein of human Thrombospondin 1 (aa 547-1170).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.60 mg/mL

Amount

60 µg

Purification

Protein A/G

Storage buffer

50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl

Contains

0.01% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3705268

Product Specific Information

Immunogen sequence: PIDGCLSNPC FAGVKCTSYP DGSWKCGACP PGYSGNGIQC TDVDECKEVP DACFNHNGEH RCENTDPGYN CLPCPPRFTG SQPFGQGVEH ATANKQVCKP RNPCTDGTHD CNKNAKCNYL GHYSDPMYRC ECKPGYAGNG IICGEDTDLD GWPNENLVCV ANATYHCKKD NCPNLPNSGQ EDYDKDGIGD ACDDDDDNDK IPDDRDNCPF HYNPAQYDYD RDDVGDRCDN CPYNHNPDQA DTDNNGEGDA CAADIDGDGI LNERDNCQYV YNVDQRDTDM DGVGDQCDNC PLEHNPDQLD SDSDRIGDTC DNNQDIDEDG HQNNLDNCPY VPNANQADHD KDGKGDACDH DDDNDGIPDD KDNCRLVPNP DQKDSDGDGR GDACKDDFDH DSVPDIDDIC PENVDISETD FRRFQMIPLD PKGTSQNDPN WVVRHQGKEL VQTVNCDPGL AVGYDEFNAV DFSGTFFINT ERDDDYAGFV FGYQSSSRFY VVMWKQVTQS YWDTNPTRAQ GYSGLSVKVV NSTTGPGEHL RNALWHTGNT PGQVRTLWHD PRHIGWKDFT AYRWRLSHRP KTGFIRVVMY EGKKIMADSG PIYDKTYAGG RLGLFVFSQE MVFFSDLKYE CRDP

Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 54%, Pig - 99%, Cynomolgus monkey - 99%.

Target Information

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: glycoprotein G; Thrombospondin; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; unnamed protein product

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Gene Aliases: tbsp1; THBS; THBS-1; TSP; TSP-1; TSP1

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UniProt ID: (Human) P07996

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Entrez Gene ID: (Human) 7057, (Mouse) 21825

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Function(s)
phosphatidylserine binding fibronectin binding protease binding endopeptidase inhibitor activity integrin binding extracellular matrix structural constituent calcium ion binding protein binding heparin binding fibroblast growth factor binding low-density lipoprotein particle binding protein homodimerization activity laminin binding proteoglycan binding transforming growth factor beta binding extracellular matrix binding fibrinogen binding collagen V binding
Process(es)
response to hypoxia negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion sprouting angiogenesis chronic inflammatory response negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation positive regulation of immune system process inflammatory response immune response cell adhesion positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus response to mechanical stimulus response to glucose positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of plasma membrane long-chain fatty acid transport negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration regulation of cell-substrate adhesion cell migration negative regulation of angiogenesis positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway response to magnesium ion response to progesterone negative regulation of interleukin-10 production negative regulation of interleukin-12 production negative regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production positive regulation of transforming growth factor beta1 production response to testosterone cellular response to heat response to endoplasmic reticulum stress nitric oxide-cGMP-mediated signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation positive regulation of macrophage activation negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain blood vessel morphogenesis positive regulation of smooth muscle cell proliferation positive regulation of chemotaxis response to calcium ion negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of fibrinolysis cellular response to tumor necrosis factor cellular response to growth factor stimulus endothelial cell-cell adhesion positive regulation of transforming growth factor beta production blood coagulation, fibrin clot formation negative regulation of cell migration involved in sprouting angiogenesis negative regulation of nitric oxide-cGMP mediated signal transduction positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of sprouting angiogenesis positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis negative regulation of extrinsic apoptotic signaling pathway outflow tract morphogenesis endocardial cushion development growth plate cartilage development positive regulation of cell-substrate adhesion monocyte aggregation cellular response to nitric oxide
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