Suggested positive control: HUVEC cells, breast carcinoma.
Platelet - derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their correspondingbases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also invoved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ECGF1; endothelial cell growth factor 1 (platelet-derived); Gliostatin; hPD-ECGF; MNGIE; PD-ECGF; PDECGF; platelet derived growth factor, endothelial cell; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP
Gene Aliases: 2900072D10Rik; ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PD-ECGF; PDECGF; Pdgfec; TP; TYMP