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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human Thymidylate Synthase|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Western Blot (WB)||See 2 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||See 1 publications below|
Thymidylate Synthase (TS) (EC 126.96.36.199) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Impact of intratumoral expression levels of fluoropyrimidine-metabolizing enzymes on treatment outcomes of adjuvant S-1 therapy in gastric cancer.
35-5800 was used in immunohistochemistry - paraffin section to identify biomarkers relevant to treatment outcomes in gastric cancer patients receiving adjuvant S-1 chemotherapy.
|Kim JY,Shin E,Kim JW,Lee HS,Lee DW,Kim SH,Lee JO,Kim YJ,Kim JH,Bang SM,Ahn SH,Park do J,Lee JS,Lee JS,Kim HH,Lee KW||PloS one (10:null)||2015|
The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells.
35-5800 was used in western blot to evaluate the therapeutic potential of oligonucleotide F10 against against acute lymphoblastic leukemia
|Pardee TS,Stadelman K,Jennings-Gee J,Caudell DL,Gmeiner WH||Oncotarget (5:4170)||2014|
|Mouse||Not Cited||The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.||Misra UK,Akabani G,Pizzo SV||The Journal of biological chemistry (277:36509)||2002|
Phase 2 trial of oxaliplatin and pemetrexed as an induction regimen in locally advanced head and neck cancer.
35-5800 was used in immunohistochemistry to report the results of a phase II trail to evaluate the tolerability and clinical efficacy of using oxaliplatin and pemetrexed to treat locally advanced head and neck squamous cell carcinoma.
|Gilbert J,Murphy B,Dietrich MS,Henry E,Jordan R,Counsell A,Wirth P,Yarbrough WG,Slebos RJ,Chung CH||Cancer (118:1007)||2012|
Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy.
35-5800 was used in immunohistochemistry - paraffin section to investigate the prognostic effectiveness of thymidylate synthase in the chemotherapy of malignant pleural mesothelioma
|Righi L,Papotti MG,Ceppi P,Billè A,Bacillo E,Molinaro L,Ruffini E,Scagliotti GV,Selvaggi G||Journal of clinical oncology : official journal of the American Society of Clinical Oncology (28:1534)||2010|
|Human||Not Cited||Expression of thymidylate synthase determines the response of gastric cancer patients undergoing gastrectomy to 5-fluorouracil-based adjuvant chemotherapy.||Yeh CN,Jung SM,Chen TW,Hwang TL,Jan YY,Chen MF||Langenbeck's archives of surgery / Deutsche Gesellschaft fu¿r Chirurgie (395:217)||2010|
HST422; thymidylate synthase; TMS; TSase
HST422; OK/SW-cl.29; TMS; TS; TYMS