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|Tested species reactivity||Chicken, Goat, Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Thyroglobulin isolated from human thyroid.|
|Storage buffer||ascites with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:5|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody reacts with 27S, 19S, and 12S thyroglobulin and lacks reactivity with cyogen bromide cleavage products of thyroglobulin. It cross-reacts with thryoglobulin from several species including rat, goat, chicken, and mouse. It does not cross react with different human tissues tested including kidney, ovary, endometrium, testis, salivary gland, colon, appendix, antrum, adrenal, liver, pancreas, spleen, bronchus epithelium, deodenum, parathyroid and mammary gland tissue.
The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti-thyroglobulin autoantibodies were the first factor to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (HashimotoÃs thyroiditis, GravesÃ diseases), with the highest level observed in HashimotoÃs thyroiditis. Anti-hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AITD3; congenital goiter; TGN; thyroglobulin
AITD3; cog; TG; TGN