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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a1/a2-isotype.|
|Storage buffer||HEPES, pH 7.5, with 50% glycerol, 100µg/ml BSA, 0.15M NaCl|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TRalpha and TRBeta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3 and quote;-triiodo-L-thyronine (T-3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog; AR7; avian); c-ERBA-1; c-erbA-alpha; CHNG6; EAR-7; EAR7; ERB-T-1; ERBA; ERBA-related 7; ERBA1; NR1A1; Nuclear receptor subfamily 1 group A member 1; THRA1; THRA2; thyroid hormone receptor; Thyroid hormone receptor alpha; thyroid hormone receptor alpha 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nucle; thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor; V-erbA-related protein 7
AR7; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA; THRA1; THRA2