|Tested species reactivity||Human, Mouse, Pig, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide of a.a. 13 to 32 [DPEENSARSPDGKRKRKNGQ] of human TR alpha1 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Neat|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21135 detects Thyroid Hormone Rec., alpha1/alpha2 in Human, Mouse, Rat and Porcine samples.
PA1-21135 has been successfully used in Immunohistochemistry (Paraffin) procedures.
PA1-21135 immunogen corresponds to Synthetic peptide of a.a. 13 to 32 [DPEENSARSPDGKRKRKNGQ] of human TR alpha1 protein..
Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TR alpha and TR beta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3 triiodo L thyronine (T3). Thyroid hormones, through their interaction with the thyroid receptor (TR), effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.