|Tested species reactivity||Human, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide corresponding to the N-terminal region of human THRA conjugated to KLH|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
This antibody is predicted to react with bovine, mouse and non-human primate based on 100% sequence homology.
This antibody is specific for the ~58 kDa human THR-alpha2 protein.
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TR alpha1, TR alpha2, TR beta1 and TR beta2. TR alpha1, TR beta1 and TR beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thyroid hormone receptor ¿ in breast cancer: prognostic and therapeutic implications.
MA1-4676 was used in immunohistochemistry to correlate thyroid hormone receptor alpha (THRalpha1 and THRalpha2) with survival in patients with breast cancer
|Jerzak KJ,Cockburn J,Pond GR,Pritchard KI,Narod SA,Dhesy-Thind SK,Bane A||Breast cancer research and treatment (149:293)||2015|