|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 199 of Human Thyroid Hormone Receptor beta|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
PA5-29684 targets Thyroid Hormone Receptor beta in IF and WB applications and shows reactivity with Human samples.
The PA5-29684 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 199 of Human Thyroid Hormone Receptor beta.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Thyroid Hormone Receptor-ß (TRß) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A Novel Signaling Pathway in Thyroid Cancer.
PA5-29684 was used in ChIP assay and immunohistochemistry - paraffin section to characterize a novel signaling pathway in thyroid cancer that mediates runt-related transcription factor 2 (Runx2) expression in thyroid cancer cells by thyroid hormone recep
|Carr FE,Tai PW,Barnum MS,Gillis NE,Evans KG,Taber TH,White JH,Tomczak JA,Jaworski DM,Zaidi SK,Lian JB,Stein JL,Stein GS||Endocrinology (157:3278)||2016|