|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Thyroid Peroxidase purified from human thyroid microsomes.|
|Storage buffer||tissue culture supernatant|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:25|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25524 detects Thyroid Peroxidase from human samples.
MA1-25524 has been successfully used in immunohistochemistry (paraffin) procedures. Perform heat mediated retrieval with 1 mM EDTA buffer, pH 9.0. We suggest incubation period of 30-60 minutes at room temperature.
The MA1-25524 immunogen is Thyroid Peroxidase purified from human thyroid microsomes by immunoaffinity chromatography.
Thyroid Peroxidase is a transmembrane protein of 107 kDa containing a heme prosthetic group and it is present on the apical surface of the thyroid follicular cells. It is the primary enzyme involved in thyroid hormone synthesis. Malignant thyroid tumors exhibit an anomaly in Thyroid Peroxidase resulting in lower antibody affinity. This antibody may be useful aid in the differentiation between the benign and malignant thyroid tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.