|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Avian, Rat, Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Rat TTF-1 recombinant protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-13958 targets Thyroid Transcription Factor 1 in IF and IHC (P) applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-13958 immunogen is rat TTF-1 recombinant protein.
TTF-1(Thyroid transcription factor-1) is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas. Staining with TTF-1 antibody is useful for distinguishing between tumors of lung and non-lung origin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Influence of thyroid transcription factor-1 on fluorodeoxyglucose uptake and prognosis of non-small cell lung cancer.
MA5-13958 was used in immunohistochemistry to study the correlation between fluorodeoxyglucose uptake and thyroid transcription factor-1 expression and the prognostic value in non-small cell lung cancer
|Ooi H,Chen CY,Hsiao YC,Huang WS,Hsieh BT||Anticancer research (34:2467)||2014|
In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma: a tissue microarray study of 207 cases.
MA5-13958 was used in immunohistochemistry to establish the optimal panel of immunochemical markers for distinguishing metastatic mammary carcinoma from primary lung carcinoma
|Kawaguchi KR,Lu FI,Kaplan R,Liu YF,Chadwick P,Chen Z,Brogi E,Shin SJ||Applied immunohistochemistry and molecular morphology : AIMM (22:266)||2014|
On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas.
MA5-13958 was used in immunohistochemistry to evaluate the detection of ROS1 transpositions in lung adenocarcinomas using a testing alogorithm
|Mescam-Mancini L,Lantuéjoul S,Moro-Sibilot D,Rouquette I,Souquet PJ,Audigier-Valette C,Sabourin JC,Decroisette C,Sakhri L,Brambilla E,McLeer-Florin A||Lung cancer (Amsterdam, Netherlands) (83:168)||2014|
Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: influence of ATS/ERS/IASLC guidelines.
MA5-13958 was used in immunohistochemistry to evaluate the quality of pulmonary adenocarcinoma CT-guided trans-thoracic needle biopsies in the context of the 2011 ATS/ERS/IASLC guidelines
|Ferretti GR,Busser B,de Fraipont F,Reymond E,McLeer-Florin A,Mescam-Mancini L,Moro-Sibilot D,Brambilla E,Lantuejoul S||Lung cancer (Amsterdam, Netherlands) (82:69)||2013|
Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis.
MA5-13958 was used in immunohistochemistry to report on 51 cases of neuroendocrine carcinoma of the stomach
|Ishida M,Sekine S,Fukagawa T,Ohashi M,Morita S,Taniguchi H,Katai H,Tsuda H,Kushima R||The American journal of surgical pathology (37:949)||2013|
High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases.
MA5-13958 was used in immunohistochemistry to report on 17 cases of high-grade lung adenocarcinoma with a fetal lung-like morphology
|Morita S,Yoshida A,Goto A,Ota S,Tsuta K,Yokozawa K,Asamura H,Nakajima J,Takai D,Mori M,Oka T,Tamaru J,Itoyama S,Furuta K,Fukayama M,Tsuda H||The American journal of surgical pathology (37:924)||2013|
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
MA5-13958 was used in immunohistochemistry to report on a case of miliary brain metastases from occult lung adenocarcinoma
|Kahveci R,Gürer B,Kaygusuz G,Sekerci Z||Journal of neurosciences in rural practice (3:386)||2012|
Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis.
MA5-13958 was used in immunohistochemistry to investigate the possibility of the survival and differentiation of fetal lung tissue in fibrotic lungs
|Toba H,Sakiyama S,Kenzaki K,Kawakami Y,Uyama K,Bando Y,Tangoku A||The Journal of thoracic and cardiovascular surgery (143:1429)||2012|
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
MA5-13958 was used in immunohistochemistry to report on a patient with large pulmonary meningothelial-like nodules
|Masago K,Hosada W,Sasaki E,Murakami Y,Sugano M,Nagasaka T,Yamada M,Yatabe Y||Case reports in oncology (5:471)||2012|
Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation.
MA5-13958 was used in immunohistochemistry to study a case of primary squamous cell carcinoma of the thyroid
|Ko YS,Hwang TS,Han HS,Lim SD,Kim WS,Oh SY||Pathology international (62:43)||2012|
Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.
MA5-13958 was used in immunohistochemistry to study OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines
|Rijlaarsdam MA,van Herk HA,Gillis AJ,Stoop H,Jenster G,Martens J,van Leenders GJ,Dinjens W,Hoogland AM,Timmermans M,Looijenga LH||British journal of cancer (105:854)||2011|
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.
MA5-13958 was used in immunohistochemistry to report on a case of combined small-cell carcinoma of the lung
|Pelosi G,Sonzogni A,Galetta D,Perrone F,Braidotti P,Manzotti M,Fabbri A,Spaggiari L,Veronesi G,Viale G||Virchows Archiv : an international journal of pathology (458:497)||2011|
Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.
MA5-13958 was used in immunohistochemistry to study the utility of an immunohistochemical panel in subtyping non-small cell lung carcinomas lacking morphologic differentiation
|Mukhopadhyay S,Katzenstein AL||The American journal of surgical pathology (35:15)||2011|
TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies.
MA5-13958 was used in immunohistochemistry to study the immunohistochemical expression of TTF1 in normal lung neuroendocrine cells and related tumors using two different monoclonal antibodies
|La Rosa S,Chiaravalli AM,Placidi C,Papanikolaou N,Cerati M,Capella C||Virchows Archiv : an international journal of pathology (457:497)||2010|
Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants.
MA5-13958 was used in immunohistochemistry to study the role of hypoxic environment in lung development and vascular morphogenesis
|Rajatapiti P,de Rooij JD,Beurskens LW,Keijzer R,Tibboel D,Rottier RJ,de Krijger RR||Neonatology (97:346)||2010|
Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD.
MA5-13958 was used in immunohistochemistry to study the role of the transcription factor C/EBPalpha in lung development and its potential role in COPD
|Didon L,Roos AB,Elmberger GP,Gonzalez FJ,Nord M||The European respiratory journal (35:186)||2010|
Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.
MA5-13958 was used in immunohistochemistry to detect epithelial cancers using immunocytochemistry
|Kuroda N,Hamaguchi N,Inoue K,Ohara M,Mizuno K,Hayashi Y,Lee GH||Medical molecular morphology (42:250)||2009|
Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases.
MA5-13958 was used in immunohistochemistry to investigate the prognostic value of neuroendocrine differentiation in non-small cell lung cancer
|Sterlacci W,Fiegl M,Hilbe W,Auberger J,Mikuz G,Tzankov A||Virchows Archiv : an international journal of pathology (455:125)||2009|
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
MA5-13958 was used in immunohistochemistry to report on a case of primary small cell neuroendocrine carcinoma of the kidney
|La Rosa S,Bernasconi B,Micello D,Finzi G,Capella C||Endocrine pathology (20:24)||2009|
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
MA5-13958 was used in immunohistochemistry to study the association of elevated phospho-S6 levels with metastasis in adenocarcinoma of the lung
|McDonald JM,Pelloski CE,Ledoux A,Sun M,Raso G,Komaki R,Wistuba II,Bekele BN,Aldape K||Clinical cancer research : an official journal of the American Association for Cancer Research (14:7832)||2008|
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma.
MA5-13958 was used in immunohistochemistry to study MASH1 as a marker to differentiate pulmonary small cell carcinoma from Merkel cell carcinoma
|Ralston J,Chiriboga L,Nonaka D||Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (21:1357)||2008|
AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer.
MA5-13958 was used in immunohistochemistry to study the role of aldoketo reductase1B10 in the development of lung cancer
|Li CP,Goto A,Watanabe A,Murata K,Ota S,Niki T,Aburatani H,Fukayama M||Pathology, research and practice (204:295)||2008|
Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
MA5-13958 was used in immunohistochemistry to study the diagnostic value of Pax8 and TTF-2 in thyroid epithelial neoplasms
|Nonaka D,Tang Y,Chiriboga L,Rivera M,Ghossein R||Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (21:192)||2008|
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.
MA5-13958 was used in immunohistochemistry to study the role of beta-catenin signaling in the formation and differentiation of multiple mesenchymal lineages during lung development
|De Langhe SP,Carraro G,Tefft D,Li C,Xu X,Chai Y,Minoo P,Hajihosseini MK,Drouin J,Kaartinen V,Bellusci S||PloS one (3:null)||2008|
Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis.
MA5-13958 was used in immunohistochemistry to study the immunohistopathology of mixed subtypes of adenocarcinoma of the lung
|Gamal G,Sano T,Sakurai S,Kawashima O,Sugano M,Nakajima T||Pathology international (57:765)||2007|
Primary neuroendocrine carcinoma of the breast: a case report.
MA5-13958 was used in immunohistochemistry to report on a case of primary neuroendocrine carcinoma of the breast
|Yaren A,Kelten C,Akbulut M,Teke Z,Duzcan E,Erdem E||Tumori (93:496)||2007|
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
MA5-13958 was used in immunohistochemistry to investigate the influence of Sox2 dosage on anterior foregut endoderm development
|Que J,Okubo T,Goldenring JR,Nam KT,Kurotani R,Morrisey EE,Taranova O,Pevny LH,Hogan BL||Development (Cambridge, England) (134:2521)||2007|
Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression.
MA5-13958 was used in immunohistochemistry to develop a prognostic model of non-small cell lung cancer based on protein expression patterns
|Kohri T,Sugano M,Kawashima O,Saito R,Sakurai S,Sano T,Nakajima T||Surgery today (36:1039)||2006|
Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos.
MA5-13958 was used in immunohistochemistry to examine the role of leukemia inhibitory factor and insulin-like growth factor I on lung development and vasculogenesis
|Moreno-Barriuso N,López-Malpartida AV,de Pablo F,Pichel JG||Developmental dynamics : an official publication of the American Association of Anatomists (235:2040)||2006|
Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
MA5-13958 was used in immunohistochemistry to report on a patient with pulmonary adenocarcinoma with a micropapillary component
|Kuroda N,Hamauzu T,Toi M,Yamaoka K,Miyazaki E,Hiroi M,Nakata H,Taguchi H,Enzan H||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (113:550)||2005|
The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature.
MA5-13958 was used in immunohistochemistry to study a spectrum of pulmonary mucinous cystic neoplasia cases
|Gao ZH,Urbanski SJ||American journal of clinical pathology (124:62)||2005|
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
MA5-13958 was used in immunohistochemistry to study the diagnostic value of TTF-1 and surfactant-B in lung adenocarcinoma and pleural mesothelioma
|Bakir K,Koçer NE,Deniz H,Güldür ME||Annals of diagnostic pathology (8:337)||2004|
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
MA5-13958 was used in immunohistochemistry to study the expression of the CDX-2 homeobox gene product in neuroendocrine tumors
|Barbareschi M,Roldo C,Zamboni G,Capelli P,Cavazza A,Macri E,Cangi MG,Chilosi M,Doglioni C||The American journal of surgical pathology (28:1169)||2004|
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs.
MA5-13958 was used in immunohistochemistry to investigate the diagnostic value of CDX-2 in lung metastases from colorectal carcinomas
|Barbareschi M,Murer B,Colby TV,Chilosi M,Macri E,Loda M,Doglioni C||The American journal of surgical pathology (27:141)||2003|
Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma.
MA5-13958 was used in immunohistochemistry to study the association of placental transmogrification of the the lung with pulmonary fibrochondromatous hamartoma
|Xu R,Murray M,Jagirdar J,Delgado Y,Melamed J||Archives of pathology and laboratory medicine (126:562)||2002|
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas.
MA5-13958 was used in immunohistochemistry to investigate the distinct TTF-1 and cytokeratin 20 expression profile among tumor types
|Cheuk W,Kwan MY,Suster S,Chan JK||Archives of pathology and laboratory medicine (125:228)||2001|
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
MA5-13958 was used in western blot to study transcriptional networks regulated by the Nkx2-1 transcription factor in lung development and tumors
|Tagne JB,Gupta S,Gower AC,Shen SS,Varma S,Lakshminarayanan M,Cao Y,Spira A,Volkert TL,Ramirez MI||PloS one (7:null)||2012|
Developmental origin and identity of song system neurons born during vocal learning in songbirds.
MA5-13958 was used in western blot to identify the song system neurons in songbirds
|Scott BB,Lois C||The Journal of comparative neurology (502:202)||2007|
Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity.
MA5-13958 was used in immunocytochemistry to characterize a dominant-negative mutation in PAX8 gene and its functional significance
|Grasberger H,Ringkananont U,Lefrancois P,Abramowicz M,Vassart G,Refetoff S||Molecular endocrinology (Baltimore, Md.) (19:1779)||2005|
The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription.
MA5-13958 was used in immunocytochemistry to investigate the interaction between Pax8 and TTF-1 and its role in transcription activation
|Di Palma T,Nitsch R,Mascia A,Nitsch L,Di Lauro R,Zannini M||The Journal of biological chemistry (278:3395)||2003|