MA5-15710 targets CRTC2 in FACS, IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15710 immunogen is purified recombinant fragment of human CRTC2 expressed in E. Coli.
MA5-15710 detects CRTC2 which has a predicted molecular weight of approximately 80kDa.
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
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Protein Aliases: CREB-regulated transcription coactivator 2; CRTC2; TORC-2; TORC2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2
Gene Aliases: CRTC2; TORC-2; TORC2
UniProt ID: (Human) Q53ET0
Entrez Gene ID: (Human) 200186