MA5-15812 targets CRTC3 in IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15812 immunogen is purified recombinant fragment of human CRTC3 expressed in E. Coli.
MA5-15812 detects CRTC3 which has a predicted molecular weight of approximately 68kDa.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CREB-regulated transcription coactivator 3; TORC-3; TORC3, CREB-regulated transcription coactivator 3; transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; Transducer of regulated cAMP response element-binding protein 3; transducer of regulated CREB protein 3
Gene Aliases: CRTC3; TORC-3; TORC3
UniProt ID: (Human) Q6UUV7
Entrez Gene ID: (Human) 64784