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|Tested species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15509 targets TrkA in IF and WB applications and shows reactivity with Human samples.
The MA5-15509 immunogen is purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
MA5-15509 detects TrkA which has a predicted molecular weight of approximately 87.4kDa.
This gene encodes a member of the neurotrophic tyrosine kinase receptor family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DKFZp781I14186; gp140trk; high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; p140-TrkA; slow nerve growth factor receptor; TRK; trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A; tyrosine kinase receptor A
MTC; NTRK1; p140-TrkA; TRK; Trk-A; TRK1; TRKA