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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the extracellular domain of human TrkA.|
|Purification||Ammonium sulfate precipitation|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||10 - 50 µg/ml|
|Western Blot (WB)||10 - 50 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Glycerol (1:1) may be added for additional stability.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
gp140trk; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; Oncogene TRK; Trk-A; TRK1-transforming tyrosine kinase protein; tropomyosin-related kinase A; tyrosine kinase receptor A
MTC; NTRK1; p140-TrkA; TRK; Trk-A; TRK1; TRKA