|Immunohistochemistry (IHC)||10 - 50 µg/ml|
|Western Blot (WB)||10 - 50 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from the extracellular domain of rat, mouse TrkB|
|Purification||Ammonium sulfate precipitation|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Glycerol (1:1) may be added for additional stability.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; Trk-B; TrkB tyrosine kinase; Tropomyosin-related kinase B; tyrosine kinase receptor B
Gene Aliases: GP145-TrkB; NTRK2; trk-B; TRKB
UniProt ID: (Human) Q8WXJ7
Entrez Gene ID: (Human) 4915
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