MA5-15548 targets NTRK3 in WB applications and shows reactivity with Human samples.
The MA5-15548 immunogen is purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.
MA5-15548 detects NTRK3 which has a predicted molecular weight of approximately 94kDa.
This gene encodes a member of the neurotrophic tyrosine receptor kinase family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
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Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; NTRK3; Trk-C; TRKC; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Aliases: gp145(trkC); GP145-TrkC; NTRK3; TRKC
UniProt ID: (Human) Q16288
Entrez Gene ID: (Human) 4916