|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: R(278) N Q L E K Y I S E R T I Q D(292) and synthetic peptide to the C terminus: (1090) N D L K G L L K E I A N K I K(1104).|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4282 detects the Trp-p8 protein in human samples.
PA1-4282 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~125 kDa protein representing Trp-p8 in transfected COS cells.
PA1-4282 immunizing peptide corresponds to amino acid residues 278-292 and the C terminus sequence of the human Trp-p8 protein.
A novel gene, trp-p8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. Trp-p8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, trp-p8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding trp-p8 were hardly detected or not detected in the corresponding normal human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.