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|Tested species reactivity||Human , Rat , Mouse|
|Host / Isotype||Mouse|
|Immunogen||Recombinant fragment of human Tuberin expressed in E. coli.|
|Storage buffer||PBS with 1% BSA|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Rc, Nafld, LAM, TSC4, Tcs2
tuberin, tuberous sclerosis 2 protein homolog, Tsc2, renal carcinoma, tuberous sclerosis 2 homolog protein, tuberous sclerosis 2 protein, TSC4