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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of Tyk2 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15303 targets Tyk2 in WB applications and shows reactivity with Human samples.
The MA5-15303 immunogen is purified recombinant fragment of Tyk2 expressed in E. Coli.
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IMD35; JTK1; TYK2