Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (91%), Rat (93%), Dog (91%), Pig (94%), Rabbit (93%), Chicken (80%), Sheep (93%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LB24-AB; Monophenol monooxygenase; oculocutaneous albinism IA; SK29-AB; Tumor rejection antigen AB; Tyrosinase
Gene Aliases: ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; TYR
UniProt ID: (Human) P14679
Entrez Gene ID: (Human) 7299