Immunogen sequence: FPRACVSSKN LMEKECCPPW SGDRSPCGQL SGRGSCQNIL LSNAPLGPQF PFTGVDDRES WPSVFYNRTC QCSGNFMGFN CGNCKFGFWG PNCTERRLLV RRNIFDLSAP EKDKFFAYLT LAKHTISSDY VIPIGTYGQM KNGSTPMFND INIYDLFVWM HYYVSMDALL GGSEIWRDID FAHEAPAFLP WHRLFLLRWE QEIQKLTGDE NFTIPYWDWR DAEKCDICTD EYMGGQHPTN PNLLSPASFF SSWQIVCSRL EEYNSHQSLC NGTPEGPLRR NPGNHDKSRT PRLPSSADVE FCLSLTQYES GSMDKAANFS F; Positive Samples: Rat skin; Cellular Location: Melanosome membrane, Single-pass type I membrane protein
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
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Protein Aliases: LB24-AB; Monophenol monooxygenase; oculocutaneous albinism IA; SK29-AB; Tumor rejection antigen AB; Tyrosinase
Gene Aliases: ATN; C; CMM8; OCA1; OCA1A; OCAIA; SHEP3; TYR
UniProt ID: (Human) P14679