MA5-14174 targets Tyrosinase in ICC, IF, IHC (P), and WB applications and shows reactivity with Canine, Feline, and Human samples.
The MA5-14174 immunogen is recombinant tyrosinase protein.
Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: LB24-AB; Monophenol monooxygenase; oculocutaneous albinism IA; SK29-AB; Tumor rejection antigen AB; Tyrosinase; tyrosinase (oculocutaneous albinism IA)
Gene Aliases: ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3; TYR