The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.
Protein Aliases: E2 ubiquitin-conjugating enzyme J1; HSUBC6e; MGC12555; NCUBE-1; Non-canonical ubiquitin-conjugating enzyme 1; ubiquitin conjugating enzyme E2, J1; Ubiquitin-conjugating enzyme E2 J1; ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast); ubiquitin-conjugating enzyme E2, J1, U; Yeast ubiquitin-conjugating enzyme UBC6 homolog E
Gene Aliases: CGI-76; HSPC153; HSPC205; HSU93243; NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p; UBE2J1
UniProt ID: (Human) Q9Y385
Entrez Gene ID: (Human) 51465