The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.
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Protein Aliases: CGI-76, HSPC153, HSPC205, HSU93243, MGC12555, NCUBE-1, NCUBE1, Ubc6p, HSUBC6e; E2 ubiquitin-conjugating enzyme J1; HSUBC6e; NCUBE-1; non-canonical ubiquitin conjugating enzyme 1; Non-canonical ubiquitin-conjugating enzyme 1; non-canonical ubquitin conjugating enzyme 1; ubiquitin conjugating enzyme E2, J1; Ubiquitin-conjugating enzyme E2 J1; ubiquitin-conjugating enzyme E2, J1; ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast); ubiquitin-conjugating enzyme E2, J1, U; Yeast ubiquitin-conjugating enzyme UBC6 homolog E
Gene Aliases: 0710008M05Rik; 1110030I22Rik; CGI-76; HSPC153; HSPC205; HSU93243; Ncube; NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p; UBE2J1