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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant human Ubc13|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 9 publications below|
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.
37-1100 was used in western blot to elucidate the mechanism by which STAT3 controls NF-kapaB signaling in innate immune cells.
|Zhang H,Hu H,Greeley N,Jin J,Matthews AJ,Ohashi E,Caetano MS,Li HS,Wu X,Mandal PK,McMurray JS,Moghaddam SJ,Sun SC,Watowich SS||Nature communications (5:null)||2014|
A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently.
37-1100 was used in western blot to identify E2s that regulate the activation, translocation, and enzymatic functions of Parkin during mitochondrial quality control
|Fiesel FC,Moussaud-Lamodière EL,Ando M,Springer W||Journal of cell science (127:3488)||2014|
A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways.
37-1100 was used in western blot to study the effect of a UBE2N inhibitor on neuroblastoma and its mechanism.
|Cheng J,Fan YH,Xu X,Zhang H,Dou J,Tang Y,Zhong X,Rojas Y,Yu Y,Zhao Y,Vasudevan SA,Zhang H,Nuchtern JG,Kim ES,Chen X,Lu F,Yang J||Cell death & disease (5:null)||2014|
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
37-1100 was used in western blot to identify and characterize compounds that inhibit NF-κB activation in diffuse large B-cell lymphoma cells.
|Pulvino M,Liang Y,Oleksyn D,DeRan M,Van Pelt E,Shapiro J,Sanz I,Chen L,Zhao J||Blood (120:1668)||2012|
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
37-1100 was used in western blot to study the role of ZRANB3 translocase during replication.
|Ciccia A,Nimonkar AV,Hu Y,Hajdu I,Achar YJ,Izhar L,Petit SA,Adamson B,Yoon JC,Kowalczykowski SC,Livingston DM,Haracska L,Elledge SJ||Molecular cell (47:396)||2012|
|Mouse||Not Cited||Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.||Wu X,Yamamoto M,Akira S,Sun SC||Proceedings of the National Academy of Sciences of the United States of America (106:20836)||2009|
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
37-1100 was used in western blot to investigate the potential role of the proteasome in checkpoint activation and ATM/ATR signaling in response to UV light-induced DNA damage
|Sakasai R,Tibbetts R||The Journal of biological chemistry (283:13549)||2008|
|Human||Not Cited||TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.||Ea CK,Sun L,Inoue J,Chen ZJ||Proceedings of the National Academy of Sciences of the United States of America (101:15318)||2004|
|Human||Not Cited||Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.||Habelhah H,Takahashi S,Cho SG,Kadoya T,Watanabe T,Ronai Z||The EMBO journal (23:322)||2004|
bendless protein; bendless-like ubiquitin conjugating enzyme; bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; epididymis secretory protein Li 71; UBC13; UbcH-ben; ubiquitin carrier protein N; ubiquitin conjugating enzyme E2N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yea; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-protein ligase N; yeast UBC13 homolog; yeast)
1500026J17Rik; AL022654; BB101821; BLU; HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN; UBC13; UBE2N