PA5-31809 targets UBXN1 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-31809 immunogen is recombinant protein fragment corresponding to a region within amino acids 106 and 297 of Human UBXN1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol.
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Protein Aliases: 2B28; mY33K; Protein 2B28; SAKS1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain-containing protein 1; UBXD10
Gene Aliases: 2B28; 4930455J02Rik; D19Ertd721e; SAKS1; T25529; UBXD10; UBXN1