|Tested species reactivity||Dog, Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 50-100 of human Uch-L1.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.1-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Uch-L1 is a 223 aa member of ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12) with an ubiquitin carboxyl-terminal hydrolase domain. Also known as PARK5, this protein is well known for having ubiquitin hydrolase and ligase activities and thus hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers. Research reports show that it is also involved in proteasomal degradation, a critical process for neuronal health. Uch-L1 present in all neurons is known to express specifically in neurons and in cells of the diffuse neuroendocrine system and their tumors. Over expression leads to non-small cell lung cancer while decreased expression leads to Huntington disease and Alzheimer disease. Uch-L1 is known to be highly susceptible to Parkinson disease and was found to be differentially expressed in both RCC lesions and RCC cell lines. Hence it may serve as potential biomarker for the diagnosis and prognosis of RCC patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.