Positive control: Postive Control: Jurkat Cell Lysate.
UE1A is one of seven named isoforms of UEV1. UEV1A is located in the nucleus, while iosforms 3 and 5 are found in the membrane7.
This antibody may also recognize other isoforms of UEV1A.
Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).
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Protein Aliases: CROC-1; DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; ubiquitin conjugating enzyme E2 variant 1; Ubiquitin-conjugating enzyme E2 variant 1; UEV-1
Gene Aliases: 0610011J09Rik; AI256840; CIR1; CROC-1; CROC1; D7Bwg1382e; P/OKcl.19; UBE2V; UBE2V1; UEV-1; UEV1; UEV1A