|Tested species reactivity||Human, Mouse, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (335 AGFLHSSRDSGGSKDSSC 352) of ULK1/Unc-51 protein.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
ULK1 belongs to the Ser/Thr protein kinase family. It interacts with GABARAP and GABARAPL2 and is important for vesicle transport and axonal elongation in mammalian neurons. It is involved in starvation-induced autophagy, thus maintaining homeostasis. It is co-localized in many kind of neurons such as pyramidal cells of the hippocampus, mitral cells of the olfactory bulb, and Purkinje cells of the cerebellum. ULK1 plays an essential role in neurite extension of cerebellar granule cells. It is expressed in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.