Sequence of this protein is as follows: FLRTRTTSVG PSNSGGSLCA MSGRVCVGSP PGPGFGSSPP GAEAAPSLRY VPYGASPPSL EGLITFEAPE LPEETLMERE HTDTLRHLNV MLMFTECVLD L
ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
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Protein Aliases: EC:18.104.22.168; Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2
Gene Aliases: ATG1B; KIAA0623; ULK2; Unc51.2
UniProt ID: (Human) Q8IYT8
Entrez Gene ID: (Human) 9706