ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
Protein Aliases: EC:220.127.116.11; Serine/threonine-protein kinase ULK2; Unc-51-like kinase 2
Gene Aliases: ATG1B; KIAA0623; ULK2; Unc51.2
UniProt ID: (Human) Q8IYT8
Entrez Gene ID: (Human) 9706