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Product Details
83000-5-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
240017A6
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
UNC13A, also named as KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in insulin secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Munc13-1; Protein unc-13 homolog A; unc13a
Gene Aliases: 2410078G03Rik; KIAA1032; Munc13-1; UNC13A; Unc13h1
UniProt ID: (Human) Q9UPW8, (Mouse) Q4KUS2, (Rat) Q62768
Entrez Gene ID: (Human) 23025, (Pig) 100627038, (Mouse) 382018, (Rat) 64829
positive regulation of neurotransmitter secretion
exocytosis
chemical synaptic transmission
neurotransmitter secretion
neuromuscular junction development
regulation of synaptic vesicle priming
synaptic vesicle docking
synaptic vesicle priming
synaptic vesicle maturation
synaptic transmission, glutamatergic
intracellular signal transduction
regulation of short-term neuronal synaptic plasticity
beta-amyloid metabolic process
long-term synaptic potentiation
innervation
positive regulation of dendrite extension
regulation of synaptic transmission, glutamatergic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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