Peptide sequence: NGEYVPRKSI LKSRSRENSV CSDTSESSAA EFDDRRGVLR SISCEEATCS
Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 100%; Rat: 80%
The function of the C19orf2 protein remains unknown.The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: FLJ10575; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor 1; URI1 prefoldin-like chaperone
Gene Aliases: C19orf2; NNX3; PPP1R19; RMP; URI; URI1
UniProt ID: (Human) O94763
Entrez Gene ID: (Human) 8725
Molecular Function: transcription factor