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Product Details
MA5-35788
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1498
Immunogen
A recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human USP22.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.86 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2849688
Target Information
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22
Gene Aliases: AI427806; KIAA1063; USP22; USP3L
UniProt ID: (Human) Q9UPT9, (Mouse) Q5DU02
Entrez Gene ID: (Human) 23326, (Mouse) 216825
Molecular Function:
cysteine protease
transcription, DNA-templated
ubiquitin-dependent protein catabolic process
cell cycle
embryo development
histone ubiquitination
histone deubiquitination
protein deubiquitination
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
regulation of transcription, DNA-templated
proteolysis
chromatin modification
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
protein binding
zinc ion binding
H4 histone acetyltransferase activity
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
cysteine-type endopeptidase activity
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
metal ion binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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