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Product Details
67321-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E12E3
Immunogen
USP8 Fusion Protein Ag27104
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 8; hUBPy; mUBPy; putative deubiquitinating enzyme; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8
Gene Aliases: AI574262; AW557536; HumORF8; KIAA0055; mKIAA0055; SPG59; UBPY; USP8
UniProt ID: (Human) P40818, (Mouse) Q80U87
Entrez Gene ID: (Human) 9101, (Mouse) 84092
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
SH3 domain binding
cadherin binding involved in cell-cell adhesion
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
mitotic cytokinesis
ubiquitin-dependent protein catabolic process
endosome organization
cell proliferation
protein deubiquitination
ERBB2 signaling pathway
protein K63-linked deubiquitination
protein K48-linked deubiquitination
cell-cell adhesion
proteolysis
cell cycle
Ras protein signal transduction
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
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