This antibody recognizes the N-terminal portion of ubinuclein 1 (UBN1). Western blot results show a 165 kDa band.
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIRA-binding protein; Protein VT4; Ubinuclein-1; Ubiquitously expressed nuclear protein
Gene Aliases: UBN1; VT; VT4
UniProt ID: (Human) Q9NPG3
Entrez Gene ID: (Human) 29855
Molecular Function: scaffold/adaptor protein