This antibody detects 70kD band of UBQLN1.
Immunogen sequence: MAESGESGG PPGSQDSAAG AEGAGAPAAA ASAEPKIMKV TVKTPKEKEE FAVPENSSVQ QFKEEISKRF KSHTDQLVLI FAGKILKDQD TLSQHGIHDG LTVHLVIKTQ NRPQDHSAQQ TNTAGSNVTT SSTPNSNSTS GSATSNPFGL GGLGGLAGLS SLGLNTTNFS ELQSQMQRQL LSNPEMMVQI MENPFVQSML SNPDLMRQLI MANPQMQQLI QRNPEISHML NNPDIMRQTL ELARNPAMMQ EMMRNQDRAL SNLESIPGGY NALRRMYTDI QEPMLSAAQE QFGGNPFASL VSNTSSGEGS QPSRTENRDP LPNPWAPQTS QSSSASSGTA STVGGTTGST ASGTSGQSTT APNLVPGVGA SMFNTPGMQS LLQQITENPQ LMQNMLSAPY MRSMMQSLSQ NPDLAAQMQN PDTLSAMSNP RAMQALLQIQ QGLQTLATEA PGLIPGFTPG LGALGSTGGS SGTNGSNATP SENTSPTAGT TEPGHQQFIQ QMLQALAGVN PQLQNPEVRF QQQLEQLSAM GFLNREANLQ ALIATGGDIN AAIERLLGSQ PS (1-561 aa encoded by BC010066)
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hPLIC-1; PLIC-1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; Ubiquilin-1
Gene Aliases: DA41; DSK2; PLIC-1; PLIC1; UBQLN1; UBQN; XDRP1