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|Tested species reactivity||Human|
|Published species reactivity||Human , Mouse|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Recombinant protein derived from an internal region of human ubiquilin.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Dsk2 increases the half-life of proteins destined to be degraded by the proteasome, and may modulate proteasome-mediated protein degradation. The Dsk2 protein binds UBE3A and BTRC, and interacts with the 19S proteasome subunit. In the cytoplasm, Dsk2 colocalizes with the proteasome; it is also associated with fibers in mitotic cells in the nucleus. Dsk2 is highly expressed in mitotic cells from metaphase to telophase, while expression in non-mitotic cells is very low.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.
37-7700 was used in immunohistochemistry and western blot to evaluate the diagnostic significance of ubiquilin expression in Huntington disease
|Safren N,Chang L,Dziki KM,Monteiro MJ||Brain research (1597:37)||2015|
Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE).
37-7700 was used in western blot to identify the unique SDS-PAGE pattern of nuclear proteasomes.
|Pitcher DS,de Mattos-Shipley K,Wang Z,Tzortzis K,Goudevenou K,Flynn H,Bohn G,Rahemtulla A,Roberts I,Snijders AP,Karadimitris A,Kleijnen MF||Biochimica et biophysica acta (1844:2222)||2014|
Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.
37-7700 was used in immunohistochemistry and western blot to test if overexpression of ubiquilin-1 delays or prevents neurodegeneration in R6/2 mice
|Safren N,El Ayadi A,Chang L,Terrillion CE,Gould TD,Boehning DF,Monteiro MJ||PloS one (9:null)||2014|
ALS15, HRIHFB2157, PLIC2, DSK2, N4BP4, CHAP1
Nedd4 binding protein 4, protein linking IAP with cytoskeleton 2, ubiquilin-2, ubiquitin-like product Chap1/Dsk2, Ubiquilin 2, Protein linking IAP with cytoskeleton-2, PLIC-2, hPLIC-2, HRIHFB2157