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Invitrogen
Uromodulin Monoclonal Antibody (774056)
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FIGURE: 1 / 1
Uromodulin Antibody (MA5-24374) in IHC
Physiological reports 2020 -
FIGURE 2 TGFbeta1 is produced in selected tubular segments in both vehicle and TC-treated mice. Immunofluorescence imaging of 8-um sections of fixed, frozen kidneys shows that the TGFbeta1 (red in all images) is primarily produced in the distal tubule (green, calbindin D28k) and thick ascending loop (green, Tamm-Horsfall protein [THP]), while TGFbeta1 did not colocalize with the proximal tubule (green, aqua... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-24374
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
774056
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Uromodulin Ser24-Ala618
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Tamm-Horsfall urinary glycoprotein; unnamed protein product; uromucoid; uromucoid uromucoid
Gene Aliases: THP; Urehd1; urehr4
UniProt ID: (Mouse) Q91X17
Entrez Gene ID: (Mouse) 22242
kidney development
organ or tissue specific immune response
renal water homeostasis
glomerular filtration
protein phosphorylation
lipid metabolic process
cellular calcium ion homeostasis
cellular sodium ion homeostasis
autophagy
apoptotic process
inflammatory response
response to unfolded protein
endoplasmic reticulum organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
regulation of blood pressure
response to xenobiotic stimulus
response to water deprivation
gene expression
urate transport
peptidyl-threonine phosphorylation
cellular phosphate ion homeostasis
cellular chloride ion homeostasis
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
cellular response to stress
multicellular organismal response to stress
cellular response to unfolded protein
response to endoplasmic reticulum stress
regulation of urine volume
ERAD pathway
protein transport into plasma membrane raft
citric acid secretion
multicellular organismal homeostasis
chemical homeostasis
ion homeostasis
defense response to Gram-negative bacterium
multicellular organismal water homeostasis
regulation of protein transport
phosphate ion homeostasis
chloride ion homeostasis
calcium ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
micturition
renal sodium ion absorption
urea transmembrane transport
collecting duct development
juxtaglomerular apparatus development
loop of Henle development
metanephric ascending thin limb development
metanephric distal convoluted tubule development
metanephric thick ascending limb development
protein localization to vacuole
apoptotic signaling pathway
connective tissue replacement
urate salt excretion
antibacterial innate immune response
neutrophil migration
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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