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Immunogen sequence: VNKAQVKIRA KKDNVAGVTL PVFEHYHEGT DSYELTGLAR GGEQLAKLKR NYAKAVELLV ELASLQTSFV TLDEAIKIT
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATPase, H+ transporting lysosomal, member M; ATPase, H+ transporting, lysosomal (vacuolar proton pump); ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D; H(+)-transporting two-sector ATPase, subunit M; V-ATPase 28 kDa accessory protein; V-ATPase D subunit; V-ATPase subunit D; V-type proton ATPase subunit D; vac; vacuolar ATP synthase subunit D; vacuolar H-ATPase subunit D; vacuolar proton pump D subunit; vacuolar proton pump delta polypeptide; Vacuolar proton pump subunit D; vacuolar proton-ATPase subunit D
Gene Aliases: ATP6M; ATP6V1D; VATD; VMA8
UniProt ID: (Human) Q9Y5K8
Entrez Gene ID: (Human) 51382
Molecular Function: ATP synthase